PERFORMANCE EVALUATION OF DHRR-RIS BASED HP DESIGN USING MACHINE LEARNING ALGORITHMS


Barriers and enablers to recruiting participants within paediatric perioperative and anaesthetic settings: lessons learned from a trial of melatonin versus midazolam in the premedication of anxious children (the MAGIC trial)

Background: Poor recruitment is one key reason for premature closure of randomised controlled trials.The Melatonin for Anxiety prior to General Anaesthesia In Children (MAGIC) trial was a multicentre randomised controlled trial of melatonin vs midazolam in the premedication of anxious children, before surgery.The trial ran between 2019 and 2022, cl

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Osteoporosis: Current review

Although hormone therapy using estrogens plus progestogens (EPT) is effective for the management of Sifters menopausal symptoms (e.g., vasomotor symptoms and vulvar/vaginal atrophy) and prevention/treatment of postmenopausal osteoporosis, EPT is associated with safety and tolerability concerns.A new alternative to EPT is the tissue selective estrog

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